Mobility of ionic hydrates
Jun/18 paper in Nature about mobility of ionic hydrates studied by high-resolution AFM. »more info

O. Wichterle prize
Jun/18 O. Stetsovych received O. Wichterle prize for outstanding young scientists at the AS CR. »more info

Piezoelectricity of single molecules
Jan/18 paper in JACS demonstrating piezoelectric effect on single molecules »more info

Resolving water clusters with AFM
Jan/18 paper in Nature Comm. about a method allowing high-resolution AFM of weakly coupled clusters »more info

High-resolution SPM imaging
Sep/17 paper in PRL reporting AFM/STM/IETS imaging »more info

Electronegativity of atoms
May/17 paper in Nature Comm. »more info

Transfer of chirality
Feb/17 Paper published in Nature Chemistry including News&Views. »more info

Towards chemical recognition of molecules
Aug/16 Paper published in ACS Nano. »more info

Odehnal award
June/16 O. Stetsovych received Odehnal award »more info

Praemium Academiae
June/16 P. Jelinek received CAS award »more info

Imaging electrostatic field
May/16 paper in Nature Comm. »more info

O. Wichterle prize
May/16 P. Hapala received O. Wichterle prize for outstanding young scientists at the AS CR. »more info

On-surface chemical synthesis
Apr/16 paper in JACS »more info

Structural and Electronic Properties of Nitrogen-Doped Graphene
Mar/16 Paper in Phys. Rev. Lett. »more info

Role of the electrostatic force in AFM images
Mar/16 Paper in Phys. Rev. Lett »more info

Charge transport between two molecules
Sep/15 Paper in Phys. Rev. Lett »more info

The best poster ECOSS-31
Sep/15 Our work has been selected as the best poster in the ECOSS-31 conference. »more info

Paper in ACS Nano
Aug/15 Novel way of B,N-co doping of graphene demonstrated. »more info

paper in PRL and Physics
Aug/15 Our work has been published in Phys. Rev. Lett highlighted as Synopsis in Physics. »more info

Paper in Nature Comm.
Jul/15 High-resolution AFM images reported at room temperature. »more info

Paper in Nano Letters
Jun/15 The current and the force used for controlled atomic switching of silicon tetramer. »more info

O. Wichterle prize
May/15 M. Ondracek received O. Wichterle prize for outstanding young scientists at the AS CR. »more info

Transfer of chirality

 Resolving transformations of molecules and their chirality in the submolecular scale

Scientists from the Institute of Physics and the Institute of Organic Chemistry and Biochemistry of Czech Academy of Sciences observed a chemical transformation of individual molecules on silver surface and demonstrated chirality transfer during the reaction. They employed the latest advances of scanning probe microscopy, which allows scientists to determine the chemical bond between individual atoms within molecules and thus determine their molecular structure and the chirality. The results were published in the prestigious journal Nature Chemistry.

Chirality is a geometrical property an object (usually a molecule or ion) that cannot be matched with its mirror image. Chirality plays a key role in nature and can be demonstrated for example on the relationship of right and left hand, which are not identical in terms of symmetry. The phenomenon of chirality is important in many areas e.g. stereoselective reactions, self-assembly of molecules, biological processes (where proteins, nucleic acids or polysacharides are involved), the polarization of light or electron spin. Control of chirality in chemical reactions in solutions represents one of the greatest achievements of organic chemistry in the last fifty years.

Molecules that are not chiral in solution or gas phase (i.e. prochiral), may become chiral under certain conditions, specifically after adsorption to a solid surface, when a so-called chiral adsorbate is formed. The breakthrough method, that allows one to create an extensive two-dimensional molecular layer of chosen chirality, was developed through the combined efforts of researchers from the Institute of Physics and the Institute of Organic Chemistry and Biochemistry of Czech Academy of Sciences, led by Dr. Pavel Jelinek and Dr. Ivo Stary. This achievement represents the first practical demonstration of the possibility that prochiral molecules at solid surfaces occupy either right or left-handed orientation on purpose.

Namely, the Czech scientists achieved that the adsorbed molecules adopted a single chirality in their whole monolayer, by using a thermally controlled chemical transformation of chiral helical molecules, so-called Helicenes to planar polyaromatic molecules (see Fig.1). The transformation was made on a surface of a silver crystal. Moreover, the scientists could accurately determine a sequence of multi-step chemical transformations of the molecules using atomic force microscope that operates at temperatures close to the absolute zero and under conditions of ultra-high vacuum. They managed to identify both intermediates and final products of the cascade of chemical reactions, employing the unique submolecular resolution that allowed the direct deduction of the molecular structures of the relevant molecules (see Fig.2).

This work represents a revolutionary approach enabling in-depth studies of chemical reactions on solid state surfaces and a precise determination of the chemical structure of molecules, with the possiblity to track conversions of their chirality. The original method opens up new possibilities for the preparation of well-defined chiral surfaces that have significant potential for use in the field of heterogeneous catalysis, sensors of chirality, molecular electronics, spintronics, photonics and biochemistry.


Fig.1. Schematic view of the chirality-preserving transformation of molecules deposited on a solid surface (A) using a temperature-controlled chemical reaction (T1). This reaction allows to get the same chirality of adsorbed molecules across the whole monolayer (green frame). Importantly, this chiral arrangement cannot be reached by simple deposition of the prochiral molecules onto the surface (B and C).


Fig.2. Molecular structures of polyaromatic molecules obtained during different stages of the chemical transformation on a crystalline silver surface (a-c). The accurate determination of the chemical structure of the individual products was carried out using scanning probe microscopes with high spatial resolution (d-k,l-o). The cascade of chemical reactions transforming the initial helicene molecules (DBH) into various intermediates and final products is schematically illustrated in (p).

From helical to planar chirality by on-surface chemistry
O. Stetsovych et al,. Nature Chemistry 9, 213 - 218 (2017).

see also News & Views Surface chemistry: Single handedness in flatland written by K.H. Ernst